Validus Cellular Therapeutics
Validus Cellular Therapeutics

Concept Mechanism of Action

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Making a Novel Cell Therapy

Background Research

Discovery

recruitment of Immune Cells

CellS Migrate to Infection

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Validus' initial discovery started in the laboratory of Dr. Steven Dow, a renowned veterinary scientist at Colorado State University.

CellS Migrate to Infection

recruitment of Immune Cells

CellS Migrate to Infection

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Unactivated mesenchymal stem cells have failed as therapeutics previously due to inability to locate to functional sites. Validus' activated MSCs migrate the to infection. 

recruitment of Immune Cells

recruitment of Immune Cells

recruitment of Immune Cells

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Activated mesenchymal stem cells recruit professional immune cells to the  site of the infection to improve clearance.

Improve infection Clean-up

Improve infection Clean-up

recruitment of Immune Cells

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Professional immune cells responding to infection, neutrophils, are more active engulfing bacteria when stimulated by activated mesenchymal stem cells.

Treat chronic infection

Improve infection Clean-up

Treat chronic infection

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Human activated mesenchymal stem cells were used to treat a chronic S. aureus infection in study mice. 

Rebuilding Correctly

Improve infection Clean-up

Treat chronic infection

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Activated mesenchymal stem cells recruit more "M2 polarity" macrophage (green) compared to "M1 polarity"  macrophage (red). M2 macrophage are responsible for tissue repair and rebuilding whereas M1 macrophage result in breakdown and inflammation.

The importance of the appropriate Immune response

M1 verses M2 Macrophage polarity

Bohlson et al. and others have described the importance of appropriate immune response require to resolve a chronic infection. Frequently, the presence of a medical device or bacteria biofilm will lock the human body's immune response to infection in a persisting inflammatory state.  This overly inflammatory state prevents the body's own tissue from healing appropriately. The immune response must transition to rebuilding and resolving prior to healing occurring.


Validus has found that infusing activated mesenchymal cells into animals with chronic infections helps shift the immune response from primarily inflammatory to primarily resolving. 

Bohlson et al. 2014 Frontiers in Immunology